Understanding the genetics of alcohol sensitivity and tolerance
Official title: Translational genetic analysis in human and mouse GWAS to identify the genomic architecture of alcohol sensitivity and tolerance
Funded at Indiana University Indianapolis · NIH-10879402 · Data updated 2026-11-12
This study is looking at how our genes might affect how sensitive or tolerant we are to alcohol, which can help us understand alcohol use disorder better and improve ways to prevent and treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Indiana University Indianapolis NIH-funded |
| Lab location | 1 site (Indianapolis, United States) |
| Project start | September 9, 2024 |
| Project end | June 30, 2029 |
| Funding year | 2024 |
| Award (this year) | $574,808 |
| NIH project number | 1R01AA031176-01A1 |
| Project ID | NIH-10879402 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of alcohol use disorder, particularly those of African ancestry.
✕Less likely to help
Patients who do not have a history of alcohol use disorder or those who do not identify with African ancestry may not benefit from this research.
What this research studies
This research investigates the genetic factors that contribute to alcohol use disorder (AUD), focusing on how sensitivity and tolerance to alcohol can vary among individuals. By analyzing genetic data from both humans and mice, the study aims to identify specific genes associated with these traits. The approach includes examining endophenotypes, which break down AUD into more manageable components for genetic analysis. This could lead to a better understanding of the genetic architecture of AUD and inform future prevention and treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for individuals with alcohol use disorder.
How similar studies have gone: Previous research has shown success in identifying genetic factors related to alcohol use disorder through genome-wide association studies, indicating that this approach has potential for further discoveries.
Where this research is happening
-
Indiana University Indianapolis
Indianapolis, United States Active
Researchers
- Principal investigator: Lai, Dongbing — Indiana University Indianapolis
- Study coordinator: Lai, Dongbing
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.