Understanding the genetics of a gene related to Barrett's esophagus and its cancer risk
Official title: Deciphering the Molecular Genetics of VSIG10L in Barrett's Neoplasia
Funded at Case Western Reserve University · NIH-10932156 · Data updated 2026-11-12
This study is looking into how certain genes, especially one called VSIG10L, might play a role in Barrett's esophagus, a condition that can lead to esophageal cancer, to help find better ways to prevent and treat it for people at risk.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | September 20, 2023 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $507,720 |
| NIH project number | 5P01CA269019-02 |
| Project ID | NIH-10932156 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with Barrett's esophagus who are at risk of developing esophageal adenocarcinoma.
✕Less likely to help
Patients without Barrett's esophagus or those with other unrelated gastrointestinal conditions may not benefit from this research.
What this research studies
This research investigates the genetic factors associated with Barrett's esophagus (BE), a condition that increases the risk of developing esophageal adenocarcinoma. The team aims to identify the mechanisms that lead to the onset and progression of BE by studying a specific gene, VSIG10L, which has been linked to the disease. Using mouse models, researchers will explore how mutations in this gene affect the integrity of the esophageal lining and contribute to cancer development. The findings could lead to the development of biomarkers and preventive strategies for patients at risk.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and prevention strategies for esophageal cancer in patients with Barrett's esophagus.
How similar studies have gone: Previous research has shown promise in understanding genetic factors related to cancer risk, making this approach both relevant and potentially impactful.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Chak, Amitabh — Case Western Reserve University
- Study coordinator: Chak, Amitabh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.