Understanding the genetics behind severe sleep apnea and its related airway structures
Genetics of Extreme Phenotypes of OSA and Associated Upper Airway Anatomy
['FUNDING_P01'] · UNIVERSITY OF PENNSYLVANIA · NIH-10880318
This study is looking at how our genes and the shape of our airways can affect obstructive sleep apnea, so we can better understand the condition and help create more personalized treatments for people who have it.
Quick facts
| Phase | ['FUNDING_P01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF PENNSYLVANIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10880318 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors that contribute to obstructive sleep apnea (OSA) by examining the anatomy of the upper airway and identifying extreme phenotypes of the condition. Using advanced imaging techniques like MRI and CT scans, researchers will analyze anatomical features that are known to increase the risk of OSA, such as the size of soft tissue structures and the shape of the craniofacial skeleton. The study aims to link these anatomical traits with genetic variations through genome-wide association studies, ultimately enhancing the understanding of how genetics influence the severity of OSA. Patients may benefit from improved risk assessment and personalized treatment strategies based on their genetic and anatomical profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with obstructive sleep apnea, particularly those with severe or extreme forms of the condition.
Not a fit: Patients without a diagnosis of obstructive sleep apnea or those with mild forms of the condition may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better identification and management of patients at risk for severe obstructive sleep apnea.
How similar studies have performed: Previous research has shown success in using genetic and anatomical analyses to understand complex conditions like OSA, suggesting that this approach has potential for meaningful insights.
Where this research is happening
PHILADELPHIA, UNITED STATES
- UNIVERSITY OF PENNSYLVANIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: SCHWAB, RICHARD J. — UNIVERSITY OF PENNSYLVANIA
- Study coordinator: SCHWAB, RICHARD J.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.