Understanding the genetics behind preference for amphetamines
Official title: Genetics of Amphetamine Preference
Funded at University of Utah · NIH-11080959 · Data updated 2026-11-12
This study is looking at how our genes might affect why some people prefer amphetamines, which can lead to addiction, and it’s for anyone interested in understanding more about the biological reasons behind substance use and how we might improve treatment options.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | May 1, 2024 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $191,521 |
| NIH project number | 5R21DA060453-02 |
| Project ID | NIH-11080959 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of amphetamine use or those at risk for substance use disorders.
✕Less likely to help
Patients who do not have a history of substance use or are not genetically predisposed to addiction may not benefit from this research.
What this research studies
This research investigates how genetic factors influence the preference for amphetamines, a class of drugs associated with substance use disorders. By studying both human genetic data and model organisms like fruit flies, the research aims to identify specific genes and genetic variations that contribute to addiction. The approach includes analyzing behavioral responses to drugs and exploring the underlying biological mechanisms. This could lead to a better understanding of addiction and inform future treatment strategies.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments for individuals struggling with substance use disorders.
How similar studies have gone: Previous research has successfully utilized genetic models to study addiction, indicating that this approach has potential for meaningful insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Rothenfluh, Adrian — University of Utah
- Study coordinator: Rothenfluh, Adrian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.