Understanding the genetics behind osteoarthritis risk and progression
Genetics of Osteoarthritis Susceptibility, Heterogeneity and Progression
This study is looking at how our genes might make some people more likely to get osteoarthritis and how it gets worse over time, and it’s especially for those who haven’t been studied much before; by sharing some of your genetic information and health details, you can help us find better, personalized treatments for OA.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Alabama at Birmingham NIH-funded |
| Lab location | 1 site (Birmingham, United States) |
| Project ID | NIH-10980179 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to osteoarthritis (OA) susceptibility and its progression. By analyzing genetic variations, the study aims to identify specific genes associated with OA, which could lead to personalized treatment approaches. The research will focus on understanding how these genetic factors differ by joint site and sex, particularly in populations that have been underrepresented in previous studies. Patients may be involved in providing genetic samples and health data to help uncover these associations.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of osteoarthritis or those experiencing symptoms of the condition.
Not a fit: Patients with osteoarthritis who do not have a genetic predisposition or those who are not interested in genetic research may not benefit from this study.
Why it matters
Potential benefit: If successful, this research could lead to more effective, personalized strategies for preventing and treating osteoarthritis.
How similar studies have performed: Previous research has shown promising results in identifying genetic factors related to osteoarthritis, indicating that this approach has potential for success.
Where this research is happening
Birmingham, United States
- University of Alabama at Birmingham — Birmingham, United States (Active)
Researchers
- Principal investigator: Mcdonald Donnelly, Merry-Lynn Noelle — University of Alabama at Birmingham
- Study coordinator: Mcdonald Donnelly, Merry-Lynn Noelle
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.