Understanding the genetics behind impulsivity and motivation in addiction
Official title: The Genetics of Impulsivity and Motivation
Funded at University of Utah · NIH-10879132 · Data updated 2026-11-12
This study is looking at how certain genes might affect impulsivity and motivation, which are important for understanding substance use disorders, using fruit flies to see how they choose food when faced with different rewards and challenges.
Quick facts
| Grant type | R21 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Utah NIH-funded |
| Lab location | 1 site (Salt Lake City, United States) |
| Project start | July 1, 2023 |
| Project end | June 30, 2025 |
| Funding year | 2024 |
| Award (this year) | $231,000 |
| NIH project number | 5R21DA056241-02 |
| Project ID | NIH-10879132 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals over 21 years old who may have a history of impulsivity or substance use disorders.
✕Less likely to help
Patients who do not have issues related to impulsivity or substance use disorders may not benefit from this research.
What this research studies
This research investigates the genetic factors that influence impulsivity and motivation, which are critical behaviors associated with substance use disorders. By using the vinegar fly, Drosophila melanogaster, as a model organism, the study aims to identify and validate specific genes linked to these behaviors. The researchers have developed a novel Fly Liquid-food Electroshock Assay (FLEA) to assess how flies make choices between different food options under varying conditions of shock and reward. This approach allows for a deeper understanding of the biological mechanisms underlying addiction-related behaviors.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic basis of addiction, potentially informing more effective treatments for individuals struggling with substance use disorders.
How similar studies have gone: Previous studies using genetic models like Drosophila have shown promise in understanding addiction behaviors, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Utah
Salt Lake City, United States Active
Researchers
- Principal investigator: Rothenfluh, Adrian — University of Utah
- Study coordinator: Rothenfluh, Adrian
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.