Understanding the genetics behind human skin color variation
Genetic and molecular basis for variation in human skin pigmentation
This study is looking at how our genes affect skin color, especially in different African communities, to better understand what makes our skin tone unique and how it helps protect us from the sun.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Children's Hosp of Philadelphia NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10835886 on NIH RePORTER |
What this research studies
This research investigates the genetic and molecular factors that contribute to differences in skin pigmentation among humans, particularly focusing on diverse African populations. By analyzing genetic data from 1600 individuals, the team aims to identify specific genes and mechanisms that influence skin tone and protect against ultraviolet radiation. The study employs advanced techniques such as genome-wide association studies to uncover novel insights into melanocyte biology and potential links to melanoma risk and rare genetic disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals from diverse ethnic backgrounds, particularly those with varying skin tones, especially within African populations.
Not a fit: Patients with skin pigmentation disorders unrelated to genetic variation or those not representative of the studied populations may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding of skin pigmentation, which may enhance prevention strategies for skin-related conditions and inform personalized medicine approaches.
How similar studies have performed: Previous research has successfully identified genetic factors influencing pigmentation in animal models, but this study aims to explore these mechanisms specifically in humans, making it a novel approach.
Where this research is happening
Philadelphia, United States
- Children's Hosp of Philadelphia — Philadelphia, United States (Active)
Researchers
- Principal investigator: Marks, Michael S — Children's Hosp of Philadelphia
- Study coordinator: Marks, Michael S
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.