Understanding the genetics behind heart rhythm problems after heart surgery
Genomics of Post-Operative Atrial Fibrillation After Cardiac Surgery
This study is looking at how our genes might play a role in causing heart rhythm problems after surgery for people having heart operations, and it's for patients who want to understand their risk of developing these issues.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Johns Hopkins University NIH-funded |
| Lab location | 1 site (Baltimore, United States) |
| Project ID | NIH-10985437 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to post-operative atrial fibrillation (poAF) in patients undergoing cardiac surgery. By analyzing atrial tissue collected during surgery, the study aims to identify genetic and epigenetic mechanisms that lead to poAF, which affects about 30% of patients in normal sinus rhythm. The research will focus on a cohort of 200 patients, primarily of European descent, to better understand how genetic variations influence heart tissue responses and the development of poAF. The findings could help improve patient outcomes by identifying those at higher risk for this complication.
Who could benefit from this research
Good fit: Ideal candidates for this research are patients scheduled for cardiac surgery who are in normal sinus rhythm and are primarily of European descent.
Not a fit: Patients who have existing atrial fibrillation or other significant cardiac conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better risk assessment and management strategies for patients undergoing cardiac surgery, potentially reducing the incidence of poAF and its associated complications.
How similar studies have performed: Previous research has identified genetic variants associated with atrial fibrillation, suggesting that this approach has potential for success in understanding poAF.
Where this research is happening
Baltimore, United States
- Johns Hopkins University — Baltimore, United States (Active)
Researchers
- Principal investigator: Muehlschlegel, Jochen Daniel — Johns Hopkins University
- Study coordinator: Muehlschlegel, Jochen Daniel
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.