Understanding the genetics behind aging-related dementia and TDP-43 pathology
Official title: Genetic Architecture of Aging-Related TDP-43 and Mixed Pathology Dementia
Funded at University of Kentucky · NIH-10658215 · Data updated 2026-11-12
This study is looking at how our genes might play a role in aging-related dementia, especially a type that affects many older adults, to better understand what makes the condition worse and how it varies from person to person.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Kentucky NIH-funded |
| Lab location | 1 site (Lexington, United States) |
| Project start | April 15, 2023 |
| Project end | March 31, 2026 |
| Funding year | 2023 |
| Award (this year) | $1,714,473 |
| NIH project number | 1RF1AG082339-01 |
| Project ID | NIH-10658215 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are elderly individuals diagnosed with dementia, particularly those exhibiting symptoms related to TDP-43 pathology.
✕Less likely to help
Patients with non-aging-related forms of dementia or those without any cognitive impairment may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to aging-related dementia, particularly focusing on TDP-43 pathology, which affects over 30% of elderly individuals with dementia. The study aims to identify distinct genetic risk factors and understand how they influence the progression and severity of this condition. By assembling comprehensive datasets that include clinical and genetic information, researchers will analyze how these factors interact and contribute to different subtypes of dementia. This approach will help clarify the complex relationship between genetics and dementia pathology.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential treatments for aging-related dementias, enhancing patient care and outcomes.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to dementia, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of Kentucky
Lexington, United States Active
Researchers
- Principal investigator: Fardo, David William — University of Kentucky
- Study coordinator: Fardo, David William
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Genetic causes of age-related TDP-43 changes and mixed dementia
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.