Understanding the genetics behind age-related hearing loss
Official title: Molecular genetics of human age-related hearing loss
Funded at Stanford University · NIH-11079514 · Data updated 2026-11-12
This study is looking at how certain genes, especially one called LOXHD1, might affect hearing loss as we get older, and it aims to find ways to help delay or prevent this common issue.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project start | April 1, 2023 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $618,184 |
| NIH project number | 5R01AG081608-03 |
| Project ID | NIH-11079514 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are adults over the age of 21 who are experiencing age-related hearing loss or are at risk for developing it.
✕Less likely to help
Patients with hearing loss due to non-age-related factors, such as noise exposure or genetic disorders unrelated to aging, may not benefit from this research.
What this research studies
This research investigates the molecular pathways that contribute to age-related hearing loss (ARHL) in humans. By analyzing genetic variants associated with ARHL, the study aims to identify functional networks that could help delay or prevent this condition. The researchers will focus on a specific gene, LOXHD1, which plays a crucial role in the hearing process, and will use mouse models to explore how genetic variations affect hearing. This approach could lead to new insights into the mechanisms of hearing loss as we age.
Why it matters
Potential benefit: If successful, this research could lead to new strategies for preventing or treating age-related hearing loss, improving communication and quality of life for older adults.
How similar studies have gone: Previous research has successfully identified genetic factors associated with hearing loss, suggesting that this approach has the potential for meaningful advancements in understanding ARHL.
Where this research is happening
-
Stanford University
Stanford, United States Active
Researchers
- Principal investigator: Grillet, Nicolas — Stanford University
- Study coordinator: Grillet, Nicolas
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.