Understanding the genetics and relapse patterns of Plasmodium ovale malaria in Africa
Population genomics and relapse epidemiology of Plasmodium ovale in sub-Saharan Africa
['FUNDING_FELLOWSHIP'] · UNIV OF NORTH CAROLINA CHAPEL HILL · NIH-10901459
This study is looking at how the Plasmodium ovale malaria parasite affects children in Tanzania, especially how it can come back after they’ve been treated, to help us understand more about this type of malaria and how it spreads.
Quick facts
| Phase | ['FUNDING_FELLOWSHIP'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIV OF NORTH CAROLINA CHAPEL HILL (nih funded) |
| Locations | 1 site (CHAPEL HILL, UNITED STATES) |
| Trial ID | NIH-10901459 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic makeup and relapse patterns of the Plasmodium ovale malaria parasite, which is increasingly recognized as a significant health concern in sub-Saharan Africa. By analyzing blood samples from children and utilizing advanced molecular techniques, the study aims to uncover how this parasite behaves and spreads, particularly focusing on its ability to cause relapses after initial infections. The research will involve a cohort of Tanzanian participants who have been monitored over time for malaria recurrence, providing valuable insights into the epidemiology of this lesser-known malaria species.
Who could benefit from this research
Good fit: Ideal candidates for participation are children under 11 years old living in sub-Saharan Africa who have experienced malaria infections.
Not a fit: Patients who do not reside in sub-Saharan Africa or who are over the age of 11 may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for malaria prevention and treatment, particularly for infections caused by Plasmodium ovale.
How similar studies have performed: While research on Plasmodium falciparum is well-established, studies focusing on Plasmodium ovale are less common, making this approach relatively novel.
Where this research is happening
CHAPEL HILL, UNITED STATES
- UNIV OF NORTH CAROLINA CHAPEL HILL — CHAPEL HILL, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CAREY-EWEND, KELLY — UNIV OF NORTH CAROLINA CHAPEL HILL
- Study coordinator: CAREY-EWEND, KELLY
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.