Understanding the Genetics and Immune System in Inflammatory Bowel Disease
Official title: Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes
Funded at Sinai Health System · NIH-11141109 · Data updated 2026-11-12
This research aims to understand how genetic factors and the immune system contribute to inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Sinai Health System NIH-funded |
| Lab location | 1 site (Toronto, Canada) |
| Project start | September 30, 2002 |
| Project end | June 30, 2027 |
| Funding year | 2025 |
| Award (this year) | $392,842 |
| NIH project number | 5U01DK062423-24 |
| Project ID | NIH-11141109 on NIH RePORTER |
Who could benefit from this research
✓Could help
This research primarily uses existing data and biospecimens from patients with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
✕Less likely to help
Patients without inflammatory bowel disease or those not part of the existing registry may not directly benefit from this specific research opportunity.
What this research studies
We know that over 200 genetic differences are linked to inflammatory bowel disease (IBD), but it's still unclear how these differences or other risk factors actually cause the disease. This project builds on a large, long-term registry of IBD patients and their biological samples collected at Mount Sinai Hospital. By using advanced techniques to study cells, genes, and the immune system, we hope to uncover the underlying causes of IBD. This work will specifically focus on severe ulcerative colitis and perianal Crohn's disease, aiming to improve our understanding of these conditions.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of IBD, potentially paving the way for new and more effective treatments for patients.
How similar studies have gone: Previous genetic studies have made significant progress in identifying genetic links to IBD, providing a strong foundation for this continued work.
Where this research is happening
-
Sinai Health System
Toronto, Canada Active
Researchers
- Principal investigator: Silverberg, Mark S. — Sinai Health System
- Study coordinator: Silverberg, Mark S.
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.