Understanding the Genetics and Immune System in Inflammatory Bowel Disease
Genomic and Immunologic Characterization of Inflammatory Bowel Disease and its Phenotypes
['FUNDING_U01'] · SINAI HEALTH SYSTEM · NIH-11141109
This research aims to understand how genetic factors and the immune system contribute to inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Quick facts
| Phase | ['FUNDING_U01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | SINAI HEALTH SYSTEM (nih funded) |
| Locations | 1 site (TORONTO, CANADA) |
| Trial ID | NIH-11141109 on ClinicalTrials.gov |
What this research studies
We know that over 200 genetic differences are linked to inflammatory bowel disease (IBD), but it's still unclear how these differences or other risk factors actually cause the disease. This project builds on a large, long-term registry of IBD patients and their biological samples collected at Mount Sinai Hospital. By using advanced techniques to study cells, genes, and the immune system, we hope to uncover the underlying causes of IBD. This work will specifically focus on severe ulcerative colitis and perianal Crohn's disease, aiming to improve our understanding of these conditions.
Who could benefit from this research
Good fit: This research primarily uses existing data and biospecimens from patients with inflammatory bowel disease, including Crohn's disease and ulcerative colitis.
Not a fit: Patients without inflammatory bowel disease or those not part of the existing registry may not directly benefit from this specific research opportunity.
Why it matters
Potential benefit: If successful, this work could lead to a deeper understanding of IBD, potentially paving the way for new and more effective treatments for patients.
How similar studies have performed: Previous genetic studies have made significant progress in identifying genetic links to IBD, providing a strong foundation for this continued work.
Where this research is happening
TORONTO, CANADA
- SINAI HEALTH SYSTEM — TORONTO, CANADA (ACTIVE)
Researchers
- Principal investigator: SILVERBERG, MARK S. — SINAI HEALTH SYSTEM
- Study coordinator: SILVERBERG, MARK S.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.