Understanding the genetics and health impacts of preeclampsia in pregnant women
Integrative omics of preeclampsia in TOPMED and maternal cardiovascular health
This study is looking into the causes of preeclampsia, a serious pregnancy condition that affects some women, to better understand how it impacts their heart health later on, with the hope of finding ways to predict and treat it more effectively.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11058401 on NIH RePORTER |
What this research studies
This research investigates preeclampsia, a serious pregnancy condition characterized by high blood pressure and protein in the urine, which affects about 5% of pregnancies. The study aims to uncover the genetic and biological factors that contribute to preeclampsia and its long-term cardiovascular risks for women who have experienced it. By analyzing data from diverse pregnancy cohorts, the research will utilize advanced techniques to profile genetic, transcriptomic, proteomic, and metabolomic changes associated with preeclampsia. This comprehensive approach seeks to improve understanding of the condition and potentially lead to better predictive and therapeutic strategies for affected women.
Who could benefit from this research
Good fit: Ideal candidates for this research include pregnant women, particularly those with a history of preeclampsia or those at high risk for developing the condition.
Not a fit: Patients who are not pregnant or those who have never experienced preeclampsia may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment options for women at risk of preeclampsia and its associated cardiovascular complications.
How similar studies have performed: Previous research has shown promise in understanding preeclampsia through genetic and omic profiling, but this study aims to take a novel and comprehensive approach by integrating multiple omic data from diverse cohorts.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Saxena, Richa — Massachusetts General Hospital
- Study coordinator: Saxena, Richa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.