Understanding the genetics and brain mechanisms of aggression in fighting fish.
Official title: Genetics and neurobiology of aggression of Betta splendens
Funded at Columbia Univ New York Morningside · NIH-10902112 · Data updated 2026-11-12
This study looks at why some Siamese fighting fish are more aggressive than others by comparing specially bred fish with their calmer wild relatives, hoping to find out which genes and brain functions are behind their fighting behavior.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia Univ New York Morningside NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 15, 2023 |
| Project end | July 31, 2025 |
| Funding year | 2024 |
| Award (this year) | $125,000 |
| NIH project number | 5K99GM151689-02 |
| Project ID | NIH-10902112 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for participation or benefit from this research would be individuals interested in the genetic and neurobiological aspects of aggressive behavior, particularly those with conditions related to aggression.
✕Less likely to help
Patients who do not exhibit aggressive behaviors or have no interest in the genetic basis of aggression may not receive any benefit from this research.
What this research studies
This research investigates the genetic and neurobiological factors that contribute to aggressive behavior in Siamese fighting fish, known as Betta splendens. By comparing highly aggressive bred fish with their less aggressive wild counterparts, the study aims to identify specific genes and neuronal mechanisms that regulate aggression. The research employs advanced behavioral tests and machine-learning tools to analyze fighting behaviors, alongside genetic mapping and neuronal imaging techniques to explore how these genes affect the nervous system. This comprehensive approach could provide insights into the biological underpinnings of aggression.
Why it matters
Potential benefit: If successful, this research could lead to a better understanding of aggression, which may inform treatments for related behavioral disorders in humans.
How similar studies have gone: While the specific approach of using Betta splendens is novel, research in genetics and aggression has shown promise in other animal models, suggesting potential for success.
Where this research is happening
-
Columbia Univ New York Morningside
New York, United States Active
Researchers
- Principal investigator: Shih, Pei Yin — Columbia Univ New York Morningside
- Study coordinator: Shih, Pei Yin
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.