Understanding the genetics and biology of von Willebrand factor and von Willebrand disease
The New Zimmerman Program for the Genetics and Biology of von Willebrand Factor and von Willebrand Disease
This study is looking at how genes and biology influence a protein called von Willebrand factor, which is important for blood clotting, to better understand von Willebrand disease, especially in older adults and people of African ancestry.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Washington University NIH-funded |
| Lab location | 1 site (Saint Louis, United States) |
| Project ID | NIH-11016807 on NIH RePORTER |
What this research studies
This research investigates the genetic and biological factors that control von Willebrand factor (VWF) and the development of von Willebrand disease (VWD). It involves analyzing a large collection of genetic samples to identify variations that affect VWF levels, particularly in individuals of African ancestry and older adults. The study employs advanced techniques such as whole genome sequencing and multi-omics data analysis to uncover the underlying mechanisms of VWF regulation and dysfunction. By collaborating across multiple projects, the research aims to provide a comprehensive understanding of VWF biology and its implications for disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with low von Willebrand factor levels, particularly those of African ancestry or older adults.
Not a fit: Patients without von Willebrand disease or those who do not have low VWF levels may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment options for patients with von Willebrand disease.
How similar studies have performed: Previous research has shown promise in understanding the genetics of blood disorders, suggesting that this approach could yield valuable insights.
Where this research is happening
Saint Louis, United States
- Washington University — Saint Louis, United States (Active)
Researchers
- Principal investigator: Di Paola, Jorge a — Washington University
- Study coordinator: Di Paola, Jorge a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.