Understanding the Genetic Roots of Male Infertility
Genomics of spermatogenic impairment
['FUNDING_R01'] · OREGON HEALTH & SCIENCE UNIVERSITY · NIH-11133006
This research helps us understand the genetic reasons why some men experience severe infertility, aiming to improve diagnosis and care.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | OREGON HEALTH & SCIENCE UNIVERSITY (nih funded) |
| Locations | 1 site (PORTLAND, UNITED STATES) |
| Trial ID | NIH-11133006 on ClinicalTrials.gov |
What this research studies
Our team is working to uncover the specific genetic changes that lead to severe male infertility, especially a condition called nonobstructive azoospermia. We partner with doctors and use advanced computer tools to find new genetic causes. By understanding these genetic links, we hope to offer better ways to diagnose and treat infertility. This work also explores how male infertility might be connected to other health issues like cancer and heart disease.
Who could benefit from this research
Good fit: Men experiencing severe male infertility, particularly those with nonobstructive azoospermia, would be the focus of this research.
Not a fit: Patients whose infertility is not related to genetic factors or who are not male would not directly benefit from this specific genetic research.
Why it matters
Potential benefit: If successful, this work could lead to more accurate diagnoses and new treatment options for men with genetic forms of infertility, and provide insights into their broader health risks.
How similar studies have performed: This project builds on previous successful efforts that have already identified many new genetic causes for male infertility.
Where this research is happening
PORTLAND, UNITED STATES
- OREGON HEALTH & SCIENCE UNIVERSITY — PORTLAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: CONRAD, DONALD F. — OREGON HEALTH & SCIENCE UNIVERSITY
- Study coordinator: CONRAD, DONALD F.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, Cardiovascular Diseases