Understanding the genetic mechanisms behind arthritis
Bridging the gap between GWAS and mechanism in arthritis
This study is looking at the genes that might play a role in juvenile idiopathic arthritis and rheumatoid arthritis, hoping to find new ways to help treat these conditions by understanding how these genes affect the disease.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11048032 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to juvenile idiopathic arthritis (JIA) and rheumatoid arthritis (RA), which are inflammatory joint diseases affecting a significant portion of the population. By analyzing genome-wide association studies (GWAS), the team aims to identify regulatory variants that influence disease mechanisms. The approach includes developing experimental methods to uncover how these genetic variants interact with biological pathways involved in arthritis. Patients may benefit from insights that could lead to new treatment strategies targeting the underlying causes of their condition.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with juvenile idiopathic arthritis or rheumatoid arthritis.
Not a fit: Patients with arthritis not linked to genetic factors or those with other unrelated conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new therapeutic approaches that directly target the genetic mechanisms of arthritis, improving patient outcomes.
How similar studies have performed: Previous research using similar genetic approaches has successfully identified pathways involved in arthritis, suggesting a promising avenue for further exploration.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Nigrovic, Peter a — Boston Children's Hospital
- Study coordinator: Nigrovic, Peter a
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.