Understanding the genetic links between substance use disorders and major depression
Official title: Genetic architecture of substance use disorders and major depression
Funded at Philadelphia VA Medical Center · NIH-10930685 · Data updated 2026-11-12
This study is looking at how our genes might play a role in why some people, especially veterans, struggle with substance use issues like alcohol and prescription painkillers, along with depression, so we can find better ways to help them based on their unique genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project start | August 1, 2022 |
| Project end | July 31, 2027 |
| Funding year | 2024 |
| NIH project number | 5IK2CX002336-03 |
| Project ID | NIH-10930685 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include veterans who are experiencing alcohol use disorder or prescription opioid use disorder, particularly those with co-occurring major depressive disorder.
✕Less likely to help
Patients who do not have substance use disorders or major depression may not receive direct benefits from this research.
What this research studies
This research investigates the genetic factors that contribute to the development of substance use disorders, such as alcohol and prescription opioid use disorders, and their relationship with major depressive disorder. By analyzing a large sample of veterans, the study aims to identify shared genetic pathways that may explain why these conditions often occur together. The approach involves refining the definitions of these disorders to better understand their genetic underpinnings and improve treatment outcomes. Patients may benefit from insights that could lead to more effective interventions tailored to their specific genetic profiles.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals suffering from both substance use disorders and major depression.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to substance use disorders and depression, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Philadelphia VA Medical Center
Philadelphia, United States Active
Researchers
- Principal investigator: Hartwell, Emily — Philadelphia VA Medical Center
- Study coordinator: Hartwell, Emily
Related research
Other NIH-funded projects on the same topics.
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Genetic factors behind alcohol and opioid use disorders and depression in veterans
A study using genetic data from veterans to understand how genes contribute to co-occurring alcohol use, prescription opioid use, and depression.
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Genetic links between alcohol or opioid problems and depression
Researchers are looking for genes that may help explain why some people, especially Veterans, have both alcohol or prescription opioid problems and major depression.
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Improving contraception decisions for women with substance use disorders after childbirth
A patient-centered decision tool called MyPath aims to help postpartum women with substance use disorders choose and keep effective contraception after giving birth.
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Transforming prison care for HIV, HIV risk, and substance use disorders
A patient-friendly look at improving HIV care and prevention for people in state prisons, especially where substance use is common.
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Trans-Nordic look at extreme major depression genetics
A large genetics study is exploring what makes extreme forms of major depression unique, by studying many thousands of people and their DNA.
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Written Exposure Therapy for Veterans with PTSD and Substance Use Disorder (brief trauma treatment)
A brief trauma-focused therapy called Written Exposure Therapy is being studied to help veterans who have both PTSD and substance use disorders.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.