Understanding the genetic links between substance use disorders and major depression
Genetic architecture of substance use disorders and major depression
This study is looking at how our genes might play a role in why some people, especially veterans, struggle with substance use issues like alcohol and prescription painkillers, along with depression, so we can find better ways to help them based on their unique genetic makeup.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Philadelphia VA Medical Center NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10930685 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to the development of substance use disorders, such as alcohol and prescription opioid use disorders, and their relationship with major depressive disorder. By analyzing a large sample of veterans, the study aims to identify shared genetic pathways that may explain why these conditions often occur together. The approach involves refining the definitions of these disorders to better understand their genetic underpinnings and improve treatment outcomes. Patients may benefit from insights that could lead to more effective interventions tailored to their specific genetic profiles.
Who could benefit from this research
Good fit: Ideal candidates for this research include veterans who are experiencing alcohol use disorder or prescription opioid use disorder, particularly those with co-occurring major depressive disorder.
Not a fit: Patients who do not have substance use disorders or major depression may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved treatment strategies for individuals suffering from both substance use disorders and major depression.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to substance use disorders and depression, suggesting that this approach could yield valuable insights.
Where this research is happening
Philadelphia, United States
- Philadelphia VA Medical Center — Philadelphia, United States (Active)
Researchers
- Principal investigator: Hartwell, Emily — Philadelphia VA Medical Center
- Study coordinator: Hartwell, Emily
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.