Understanding the genetic features of high-risk gastric precancerous lesions
Project 1 - Molecular and Cellular Determinants of High Risk Gastric Precancerous Lesions
This study is looking at the early signs of high-risk stomach cancer to help us understand how they develop, especially in people with Helicobacter pylori infections, so we can find better ways to spot and prevent stomach cancer in the future.
Quick facts
| Grant type | P01 program project |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Stanford University NIH-funded |
| Lab location | 1 site (Stanford, United States) |
| Project ID | NIH-10932168 on NIH RePORTER |
What this research studies
This research investigates the molecular characteristics of high-risk gastric cancer precursor lesions to better understand their progression. The team, led by Dr. Hanlee Ji, will analyze gene expression profiles and cellular properties of these lesions using advanced techniques like RNA sequencing and spatial transcriptomics. By examining the genetic makeup of these lesions, the research aims to identify specific markers that indicate a higher risk of developing gastric cancer, particularly in patients with Helicobacter pylori infections. This work could lead to improved detection and prevention strategies for gastric cancer.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with high-risk gastric intestinal metaplasia or those with a history of Helicobacter pylori infection.
Not a fit: Patients with low-risk gastric lesions or those without any precancerous conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to earlier detection and targeted prevention strategies for patients at high risk of gastric cancer.
How similar studies have performed: Previous research has shown promise in identifying genetic markers associated with cancer progression, suggesting that this approach could yield valuable insights.
Where this research is happening
Stanford, United States
- Stanford University — Stanford, United States (Active)
Researchers
- Principal investigator: Ji, Hanlee P — Stanford University
- Study coordinator: Ji, Hanlee P
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.