Understanding the genetic factors that influence the severity of endometriosis
Official title: Disentangling the genetic mechanisms of endometriosis severity with single-cell multi-omics
Funded at University of Texas Hlth Science Center · NIH-11176357 · Data updated 2026-11-12
This study is looking at how genes might affect the severity of endometriosis, a painful condition many women experience, and it involves patients to help us learn more about the differences between mild and severe cases so we can improve treatment and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Texas Hlth Science Center NIH-funded |
| Lab location | 1 site (San Antonio, United States) |
| Project start | September 1, 2024 |
| Project end | May 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $699,329 |
| NIH project number | 5R01HD114855-02 |
| Project ID | NIH-11176357 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women of reproductive age who have been diagnosed with endometriosis.
✕Less likely to help
Patients who do not have endometriosis or are outside the reproductive age range may not benefit from this research.
What this research studies
This research investigates the genetic mechanisms that contribute to the severity of endometriosis, a condition affecting many women of reproductive age. By utilizing advanced techniques such as single-cell epigenomics and multi-omics, the study aims to analyze gene regulation and identify genetic predictors of disease outcomes. Patients will be involved in a large cohort study that provides detailed clinical information, helping to uncover the biological differences between low and high stages of endometriosis. The findings could lead to better understanding and management of this painful condition.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic tools and personalized treatment options for women suffering from endometriosis.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in other chronic conditions, suggesting potential for success in this novel approach to endometriosis.
Where this research is happening
-
University of Texas Hlth Science Center
San Antonio, United States Active
Researchers
- Principal investigator: Lawrenson, Kate — University of Texas Hlth Science Center
- Study coordinator: Lawrenson, Kate
Related research
Other NIH-funded projects on the same topics.
-
Molecular clues to endometriosis-related infertility
This grant explores how molecular changes in endometriosis contribute to infertility, with the aim of finding better ways to diagnose and treat the condition.
-
Hormonal Influences on Inflammation in Endometriosis
A study in adult women with endometriosis looks at how hormones and immune pathways interact to influence inflammation and symptoms.
-
How genes influence endometriosis in women of different racial and ethnic backgrounds
The team will compare genetic changes in tissue from women of various races who have endometriosis to find molecular targets for better treatments.
-
Quantum diamond sensor endoscopy to map iron in endometriosis
A tiny quantum sensor built into an endoscope will map iron in endometriosis lesions to help diagnose the disease noninvasively.
-
Understanding how RPLP1 affects endometriosis and adenomyosis
A patient-focused look at how a ribosomal protein called RPLP1 may drive tissue changes in endometriosis and adenomyosis and what this could mean for future therapies.
-
CXCR4 methylation in endometriosis and its role as an early biomarker and non-hormonal therapy target
This project explores how changes in CXCR4 gene regulation may help diagnose endometriosis earlier and point toward non-hormonal treatments for the condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.