Understanding the genetic factors that influence eye development and blindness
Discovery and characterization of ocular regulatory elements through evolutionary analysis
This study is looking at the genes that help form healthy eyes by comparing the DNA of animals that can see with those that can't, using zebrafish to learn more about how these genes work and what might cause blindness, which could help find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pittsburgh at Pittsburgh NIH-funded |
| Lab location | 1 site (Pittsburgh, United States) |
| Project ID | NIH-10930156 on NIH RePORTER |
What this research studies
This research investigates the genetic regulatory elements that play a crucial role in eye development by comparing the genomes of sighted and blind species. Using advanced genomic techniques, the project aims to identify specific chromosomal regions that are conserved in sighted species but are lost or deteriorating in blind species. The researchers will utilize zebrafish models to study how these genetic sequences affect eye development and function. By analyzing the differences in DNA sequences between blind and sighted species, the study seeks to uncover the underlying causes of blindness and potential pathways for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research are children aged 0-11 years who are experiencing vision problems or are at risk for developmental eye disorders.
Not a fit: Patients with fully developed eyesight and no genetic predisposition to eye disorders may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to new insights into the genetic causes of blindness and pave the way for innovative therapies.
How similar studies have performed: Previous research has shown success in using comparative genomics to identify genetic factors in other developmental conditions, suggesting a promising approach for this study.
Where this research is happening
Pittsburgh, United States
- University of Pittsburgh at Pittsburgh — Pittsburgh, United States (Active)
Researchers
- Principal investigator: Clark, Nathaniel L — University of Pittsburgh at Pittsburgh
- Study coordinator: Clark, Nathaniel L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.