Understanding the genetic factors that influence blood cell development
Determining genetic mechanisms that drive in vitro hematopoiesis
['FUNDING_CAREER'] · CHILDREN'S HOSP OF PHILADELPHIA · NIH-10878927
This study is looking at how certain genes help turn special stem cells into blood cell precursors, which could lead to better lab-made blood cell treatments for patients in need.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CHILDREN'S HOSP OF PHILADELPHIA (nih funded) |
| Locations | 1 site (PHILADELPHIA, UNITED STATES) |
| Trial ID | NIH-10878927 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic mechanisms that drive the production of hematopoietic progenitor cells (HPCs) from induced pluripotent stem cells (iPSCs). By using advanced computational modeling and in vitro culture techniques, the study aims to identify specific genes, such as Tropomyosin 1, that regulate the development of these blood cell precursors. The findings could enhance the efficiency of producing blood cells in the lab, which is crucial for developing new blood cell therapies. Patients may benefit from improved treatments derived from these advancements in blood cell production.
Who could benefit from this research
Good fit: Ideal candidates for participation or benefit from this research include individuals with blood disorders or those requiring blood cell therapies.
Not a fit: Patients with conditions unrelated to blood cell production or those not requiring blood cell therapies may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective blood cell therapies for various conditions.
How similar studies have performed: Other research has shown promise in using genetic approaches to enhance blood cell production, indicating potential success for this study.
Where this research is happening
PHILADELPHIA, UNITED STATES
- CHILDREN'S HOSP OF PHILADELPHIA — PHILADELPHIA, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: THOM, CHRISTOPHER STEPHEN — CHILDREN'S HOSP OF PHILADELPHIA
- Study coordinator: THOM, CHRISTOPHER STEPHEN
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.