Understanding the genetic factors that increase prostate cancer risk
Elucidating prostate cancer risk mechanisms through large-scale cistrome wide association studies
This study is looking into how certain genes that don’t make proteins might affect the risk of prostate cancer, and it’s for anyone interested in understanding the genetic factors behind this condition.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Dana-Farber Cancer Inst NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10894705 on NIH RePORTER |
What this research studies
This research investigates the genetic mechanisms that contribute to prostate cancer risk by focusing on non-protein coding regions of the genome. It aims to identify causal genetic variants and their target genes using advanced computational and statistical methods. By analyzing large-scale data from genome-wide association studies (GWAS), the researchers will prioritize candidate variants and validate their findings through experimental approaches. This work not only targets prostate cancer but also provides a framework applicable to other complex traits.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of prostate cancer or those who are at high risk due to genetic factors.
Not a fit: Patients with prostate cancer who are already undergoing treatment may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved risk assessment and targeted prevention strategies for prostate cancer.
How similar studies have performed: Previous research has shown success in identifying genetic variants associated with other complex traits using similar genomic approaches.
Where this research is happening
Boston, United States
- Dana-Farber Cancer Inst — Boston, United States (Active)
Researchers
- Principal investigator: Freedman, Matthew L — Dana-Farber Cancer Inst
- Study coordinator: Freedman, Matthew L
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.