Understanding the genetic factors of opioid use disorder in the brain
Official title: Deciphering the single-nucleus genomic regulatory structure of opioid use disorder in the human brain
Funded at Yale University · NIH-11106026 · Data updated 2026-11-12
This study is looking at how our genes and their changes in brain cells might affect opioid use disorder, with the goal of finding better ways to help people struggling with addiction.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | July 1, 2023 |
| Project end | May 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $502,500 |
| NIH project number | 5DP1DA058737-03 |
| Project ID | NIH-11106026 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals with a history of opioid use disorder or those at risk due to genetic factors.
✕Less likely to help
Patients who do not have a history of opioid use disorder or related genetic predispositions may not benefit from this research.
What this research studies
This research investigates the genetic and epigenetic factors contributing to opioid use disorder (OUD) by analyzing single human brain cells. It aims to profile various DNA modifications and the 3D structure of the genome to uncover how these factors influence gene regulation related to OUD. By focusing on individual cell types and brain regions, the study seeks to provide a clearer picture of the biological mechanisms underlying addiction. This approach could lead to more targeted interventions and treatments for those affected by OUD.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for individuals suffering from opioid use disorder.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in addiction, but this specific approach of analyzing single nuclei is relatively novel.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: Montalvo-Ortiz, Janitza Liz — Yale University
- Study coordinator: Montalvo-Ortiz, Janitza Liz
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.