Understanding the genetic factors of hidradenitis suppurativa across different races
Official title: Multi-racial genetic analysis of hidradenitis suppurativa
Funded at University of California, San Francisco · NIH-10889138 · Data updated 2026-11-12
This study is looking into hidradenitis suppurativa, a painful skin condition that affects people of different backgrounds, to better understand its causes and find new ways to treat it by comparing the genetics of those with the condition to healthy individuals.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project start | July 16, 2021 |
| Project end | June 30, 2026 |
| Funding year | 2024 |
| Award (this year) | $721,918 |
| NIH project number | 5R01AR078688-04 |
| Project ID | NIH-10889138 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with hidradenitis suppurativa, particularly those from diverse racial backgrounds.
✕Less likely to help
Patients who do not have hidradenitis suppurativa or those from populations not represented in the study may not benefit from this research.
What this research studies
This research investigates hidradenitis suppurativa (HS), a painful skin condition that affects various racial groups, including African Americans, Asians, and Latinos. The study employs advanced techniques such as genome-wide association studies and spatial transcriptomics to explore the genetic and biological factors contributing to HS. By comparing genetic data from affected individuals and healthy controls across different ethnicities, the research aims to uncover new insights into the disease's mechanisms and potential treatment targets.
Why it matters
Potential benefit: If successful, this research could lead to the development of new and more effective treatments for hidradenitis suppurativa.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in skin diseases, suggesting that this approach could yield valuable insights.
Where this research is happening
-
University of California, San Francisco
San Francisco, United States Active
Researchers
- Principal investigator: Liao, Wilson — University of California, San Francisco
- Study coordinator: Liao, Wilson
Related research
Other NIH-funded projects on the same topics.
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Anti-CD38 immunotherapy for severe hidradenitis suppurativa
A new treatment using anti-CD38 therapy is being tested for people with severe hidradenitis suppurativa who have not responded to prior therapies.
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Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
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Precision therapies for hidradenitis suppurativa using AI
A doctor-researcher team at UC San Francisco is using advanced computer methods to find personalized drug options to treat hidradenitis suppurativa.
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Injectable Hydrogel for HS: a localized therapy to ease painful skin disease
A new baricitinib hydrogel is being developed to deliver pain relief and reduce inflammation directly in hidradenitis suppurativa (HS) lesions, potentially lowering systemic side effects.
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Whole-genome sequencing to understand hidradenitis suppurativa in diverse groups
Researchers will study the genetic factors that contribute to hidradenitis suppurativa, especially in African American, Hispanic/Latino, and White patients, to better understand why some people are more affected.
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Understanding the Genes Behind Hidradenitis Suppurativa in teens and young adults
A study to find genetic factors that contribute to hidradenitis suppurativa (HS), a painful skin condition that often starts in adolescence and affects many Black individuals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.