Understanding the genetic factors of COPD in women
Official title: Multi-omic Characterization of COPD in Females
Funded at Pennsylvania State Univ Hershey Med Ctr · NIH-10882086 · Data updated 2026-11-12
This study is looking at how genes might affect chronic obstructive pulmonary disease (COPD) in women, using special tests on lung tissue and blood samples to find out more about the unique factors that contribute to the disease in females.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Pennsylvania State Univ Hershey Med Ctr NIH-funded |
| Lab location | 1 site (Hershey, United States) |
| Project start | August 1, 2024 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $572,076 |
| NIH project number | 1R01HL173869-01 |
| Project ID | NIH-10882086 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are women diagnosed with chronic obstructive pulmonary disease (COPD).
✕Less likely to help
Patients who are not female or do not have a diagnosis of COPD may not receive any benefit from this research.
What this research studies
This research focuses on chronic obstructive pulmonary disease (COPD) specifically in females, aiming to uncover the genetic factors that contribute to the disease. By conducting female-specific genome-wide association studies (GWAS) and analyzing single-cell RNA sequencing data from female lung tissues, the researchers will identify risk genes associated with COPD. The study also plans to create a large dataset of plasma proteomics to further understand the biological markers linked to the disease. This comprehensive approach seeks to address the unique aspects of COPD in women, which have been overlooked in previous studies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and potential new treatments for COPD specifically tailored for women.
How similar studies have gone: While there have been studies on COPD, this research is novel in its focus on female-specific genetic factors and has the potential to fill a significant gap in existing knowledge.
Where this research is happening
-
Pennsylvania State Univ Hershey Med Ctr
Hershey, United States Active
Researchers
- Principal investigator: Liu, Dajiang — Pennsylvania State Univ Hershey Med Ctr
- Study coordinator: Liu, Dajiang
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.