Understanding the genetic factors of Alzheimer's Disease and related dementias over time
Official title: Statistical Framework for Unraveling Age-Dependent Genetic Landscape of Alzheimer's Disease and Related Dementias: Harnessing Large-Scale EHR and DNA-Biobank Integration
Funded at Columbia University Health Sciences · NIH-11097265 · Data updated 2026-11-12
This study is looking at how our genes related to Alzheimer's and similar memory issues change as we get older, and it's for anyone interested in understanding more about these conditions to help improve prevention and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | June 1, 2024 |
| Project end | February 28, 2029 |
| Funding year | 2025 |
| Award (this year) | $652,682 |
| NIH project number | 5R01AG087496-02 |
| Project ID | NIH-11097265 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals of various ages who are at risk for or diagnosed with Alzheimer's Disease or related dementias.
✕Less likely to help
Patients who do not have a genetic predisposition to Alzheimer's Disease or related dementias may not benefit from this research.
What this research studies
This research investigates how genetic factors related to Alzheimer's Disease (AD) and related dementias (ADRD) change with age. By utilizing large-scale biobanks and Electronic Medical Records (EMR), the study aims to analyze the genetic architecture of these conditions across different populations and phenotypes. The researchers will develop new methods to identify age-dependent genetic changes and their interactions with other health conditions, which could lead to better understanding and prevention strategies for AD/ADRD.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and therapeutic targets for Alzheimer's Disease and related dementias.
How similar studies have gone: Previous research has shown promise in using large-scale genetic data and EMR to uncover insights into Alzheimer's Disease, indicating that this approach has potential for success.
Where this research is happening
-
Columbia University Health Sciences
New York, United States Active
Researchers
- Principal investigator: Wei, Ying — Columbia University Health Sciences
- Study coordinator: Wei, Ying
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.