Understanding the genetic factors of Alzheimer's Disease and related dementias over time
Statistical Framework for Unraveling Age-Dependent Genetic Landscape of Alzheimer's Disease and Related Dementias: Harnessing Large-Scale EHR and DNA-Biobank Integration
This study is looking at how our genes related to Alzheimer's and similar memory issues change as we get older, and it's for anyone interested in understanding more about these conditions to help improve prevention and care.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Columbia University Health Sciences NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11097265 on NIH RePORTER |
What this research studies
This research investigates how genetic factors related to Alzheimer's Disease (AD) and related dementias (ADRD) change with age. By utilizing large-scale biobanks and Electronic Medical Records (EMR), the study aims to analyze the genetic architecture of these conditions across different populations and phenotypes. The researchers will develop new methods to identify age-dependent genetic changes and their interactions with other health conditions, which could lead to better understanding and prevention strategies for AD/ADRD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals of various ages who are at risk for or diagnosed with Alzheimer's Disease or related dementias.
Not a fit: Patients who do not have a genetic predisposition to Alzheimer's Disease or related dementias may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention strategies and therapeutic targets for Alzheimer's Disease and related dementias.
How similar studies have performed: Previous research has shown promise in using large-scale genetic data and EMR to uncover insights into Alzheimer's Disease, indicating that this approach has potential for success.
Where this research is happening
New York, United States
- Columbia University Health Sciences — New York, United States (Active)
Researchers
- Principal investigator: Wei, Ying — Columbia University Health Sciences
- Study coordinator: Wei, Ying
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.