Understanding the genetic factors of Alzheimer's disease
Learning the Regulatory Code of Alzheimer's Disease Genomes
This study is looking at the genes and other biological factors that might play a role in Alzheimer's disease, using data from many people to find new ways to understand and treat the condition.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-10907546 on NIH RePORTER |
What this research studies
This research investigates the genetic and epigenetic factors contributing to Alzheimer's disease (AD) by analyzing large-scale genomic data from thousands of individuals. It employs advanced machine learning techniques to uncover new cellular processes that may lead to potential therapeutic targets beyond the traditional focus on amyloid-β aggregation. By integrating diverse datasets, including whole genome sequencing and gene expression profiles from post-mortem brains, the study aims to enhance our understanding of AD and identify new avenues for treatment.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a family history of Alzheimer's disease or those showing early signs of cognitive decline.
Not a fit: Patients with non-Alzheimer's forms of dementia or those without any genetic predisposition to Alzheimer's may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to the development of new treatments for Alzheimer's disease, improving outcomes for patients.
How similar studies have performed: Previous research has shown promise in using genomic data and machine learning to identify potential therapeutic targets in neurodegenerative diseases, indicating that this approach could be effective.
Where this research is happening
New York, United States
- Icahn School of Medicine at Mount Sinai — New York, United States (Active)
Researchers
- Principal investigator: Raj, Towfique — Icahn School of Medicine at Mount Sinai
- Study coordinator: Raj, Towfique
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.