Understanding the genetic factors linked to alcohol use disorder and related conditions
Characterizing the phenotypic spectrum associated with genetic liability for alcohol use disorder
This study is looking at how our genes might influence alcohol use disorder and its connection to other mental and physical health issues, with the goal of finding better ways to diagnose and treat people who are struggling with these challenges.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Pennsylvania NIH-funded |
| Lab location | 1 site (Philadelphia, United States) |
| Project ID | NIH-10766708 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to alcohol use disorder (AUD) and its association with other psychiatric and medical conditions. By analyzing data from over 15,000 individuals with substance use disorders, the study aims to identify specific genetic markers and phenotypes that are linked to AUD. The approach involves comprehensive psychiatric interviews and polygenic risk scoring to better understand the underlying biological pathways. This could lead to improved diagnosis and treatment strategies for individuals affected by AUD and related disorders.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals with a history of alcohol use disorder or related psychiatric conditions.
Not a fit: Patients without any history of alcohol use disorder or related psychiatric conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more accurate diagnoses and targeted treatments for patients with alcohol use disorder and co-occurring conditions.
How similar studies have performed: Previous research has shown success in identifying genetic markers associated with alcohol use disorder, suggesting that this approach has potential for meaningful insights.
Where this research is happening
Philadelphia, United States
- University of Pennsylvania — Philadelphia, United States (Active)
Researchers
- Principal investigator: Kember, Rachel Lorraine — University of Pennsylvania
- Study coordinator: Kember, Rachel Lorraine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.