Understanding the genetic factors influencing cannabis use and its effects on mental health.
Official title: Genetic Basis of the Risk and Consequences of Cannabis Exposure in Humans
Funded at Yale University · NIH-11087267 · Data updated 2026-11-12
This study is looking at how our genes might affect the risk of developing cannabis use disorder and its impact on mental health, especially for people from different backgrounds, and it invites participants to share their cannabis use and mental health experiences to help us understand these connections better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Yale University NIH-funded |
| Lab location | 1 site (New Haven, United States) |
| Project start | September 30, 2023 |
| Project end | July 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $158,513 |
| NIH project number | 3R01DA058862-02S1 |
| Project ID | NIH-11087267 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of cannabis use, particularly those with mental health conditions like depression or schizophrenia.
✕Less likely to help
Patients who do not use cannabis or have no history of mental health issues may not benefit from this research.
What this research studies
This research investigates how genetic factors contribute to the risk of developing cannabis use disorder (CanUD) and its effects on mental health, particularly in individuals with different ancestries. By analyzing genetic data from diverse populations, including those of African descent, the study aims to uncover how genetics influence responses to cannabis and its derivatives, such as cannabidiol (CBD). The research will also explore the relationship between CanUD and conditions like major depressive disorder (MDD) and schizophrenia. Participants may be involved in genetic analyses and assessments of their cannabis use and mental health.
Why it matters
Potential benefit: If successful, this research could lead to personalized treatment strategies for individuals at risk of cannabis use disorder and its associated mental health issues.
How similar studies have gone: Previous research has shown promising results in understanding the genetic basis of substance use disorders, indicating that this approach could yield valuable insights.
Where this research is happening
-
Yale University
New Haven, United States Active
Researchers
- Principal investigator: D'souza, Deepak Cyril — Yale University
- Study coordinator: D'souza, Deepak Cyril
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.