Understanding the genetic factors behind pregnancy loss
The Genomic Architecture of Pregnancy Loss
['FUNDING_R01'] · MASSACHUSETTS GENERAL HOSPITAL · NIH-10906314
This study is looking into the genetic reasons behind pregnancy loss to help families who have gone through this experience, by analyzing the DNA of at least 2,500 families to find clues that might help prevent future losses.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | MASSACHUSETTS GENERAL HOSPITAL (nih funded) |
| Locations | 1 site (BOSTON, UNITED STATES) |
| Trial ID | NIH-10906314 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic causes of pregnancy loss, which affects a significant number of pregnancies. By forming a consortium of international sites, the study aims to analyze the genomes of families who have experienced pregnancy loss, focusing on both rare genetic variations and common factors that may contribute to non-viability. The research will utilize advanced genome sequencing techniques and involve at least 2,500 families to gather comprehensive data. The goal is to identify genomic predictors that could help understand and potentially prevent future pregnancy losses.
Who could benefit from this research
Good fit: Ideal candidates for this research include families who have experienced pregnancy loss, particularly those with recurrent losses or fetal demise.
Not a fit: Patients who have not experienced pregnancy loss or those with unrelated reproductive health issues may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and prevention strategies for pregnancy loss, ultimately improving outcomes for families trying to conceive.
How similar studies have performed: Previous research has shown promise in understanding genetic factors related to pregnancy loss, but this study aims to expand on those findings with a novel and comprehensive approach.
Where this research is happening
BOSTON, UNITED STATES
- MASSACHUSETTS GENERAL HOSPITAL — BOSTON, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TALKOWSKI, MICHAEL E — MASSACHUSETTS GENERAL HOSPITAL
- Study coordinator: TALKOWSKI, MICHAEL E
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Autistic Disorder