Understanding the genetic factors behind orofacial clefts using facial measurements and genetic data
Integration of polygenic risk and facial morphometrics to decipher the genetic susceptibility of orofacial clefting
This study is looking into the genetic reasons behind orofacial clefts, which are common birth defects affecting the lip and mouth, to help identify who might be at risk based on their genes and facial features.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11004634 on NIH RePORTER |
What this research studies
This research investigates the genetic causes of orofacial clefts, which are common birth defects affecting the lip and palate. By integrating polygenic risk scores with facial morphometrics, the study aims to better understand how genetic variations contribute to these conditions. The approach involves advanced statistical methods to analyze genetic data from diverse populations, addressing challenges in accurately assessing genetic risk. This could lead to improved identification of individuals at risk for orofacial clefts based on their genetic makeup and facial characteristics.
Who could benefit from this research
Good fit: Ideal candidates for this research include children under 11 years old who have been diagnosed with orofacial clefts or have a family history of these conditions.
Not a fit: Patients who do not have orofacial clefts or a family history of these conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could enhance early identification and intervention strategies for children at risk of orofacial clefts.
How similar studies have performed: Previous research has successfully utilized polygenic risk scores in other complex genetic disorders, suggesting potential for similar success in this area.
Where this research is happening
Boston, United States
- Massachusetts General Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Brand, Harrison — Massachusetts General Hospital
- Study coordinator: Brand, Harrison
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.