Understanding the genetic factors behind neuropsychiatric disorders like autism and epilepsy
Official title: Integration of common, rare, and structural variation to define the genetic architecture of neuropsychiatric disorders
Funded at Massachusetts General Hospital · NIH-10948257 · Data updated 2026-11-12
This study is looking at the genes behind conditions like autism and epilepsy to help us understand what they have in common and what makes them different, which could lead to better ways to diagnose and treat these disorders.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Massachusetts General Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | September 1, 2024 |
| Project end | August 31, 2028 |
| Funding year | 2024 |
| Award (this year) | $183,663 |
| NIH project number | 1K01MH137407-01 |
| Project ID | NIH-10948257 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals diagnosed with autism spectrum disorder, epilepsy, or schizophrenia.
✕Less likely to help
Patients with neuropsychiatric disorders not included in this research, or those without a genetic component to their condition, may not benefit.
What this research studies
This research investigates the genetic underpinnings of neuropsychiatric disorders (NPDs) such as autism spectrum disorder (ASD) and epilepsy by analyzing both common and rare genetic variations. The approach involves extensive training in genetic analysis and the development of new statistical methods to uncover gene associations across multiple disorders. By integrating data from various NPDs, the research aims to fill gaps in our understanding of their shared and unique genetic architectures, potentially leading to better diagnostic and therapeutic strategies.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for patients with neuropsychiatric disorders.
How similar studies have gone: Previous research has shown promise in understanding genetic factors in neuropsychiatric disorders, making this approach both relevant and potentially impactful.
Where this research is happening
-
Massachusetts General Hospital
Boston, United States Active
Researchers
- Principal investigator: Fu, Jack Minyang — Massachusetts General Hospital
- Study coordinator: Fu, Jack Minyang
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.