Understanding the genetic factors behind intracranial aneurysms
Systems Genetics Approach to Intracranial Aneurysms
This study is looking at the genes and other factors that might cause brain aneurysms, which can be very serious, to help find better ways to spot people at risk and develop new treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-10661614 on NIH RePORTER |
What this research studies
This research investigates the genetic and epigenetic factors that contribute to the formation of intracranial aneurysms, which can lead to life-threatening conditions such as subarachnoid hemorrhage. By employing a systems genetics approach, the study aims to identify key biological pathways involved in aneurysm development. This could enable more effective screening and early detection of individuals at high risk for aneurysms, ultimately improving patient outcomes. The research also seeks to uncover potential new therapeutic strategies based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research include adults with a family history of aneurysms or those who have experienced symptoms related to intracranial aneurysms.
Not a fit: Patients who do not have a genetic predisposition to aneurysms or who are not at risk for developing them may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved early detection and treatment options for individuals at risk of developing intracranial aneurysms.
How similar studies have performed: Previous research has successfully identified genetic factors associated with aneurysm formation, suggesting that this approach has the potential for meaningful advancements.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Du, Rose — Brigham and Women's Hospital
- Study coordinator: Du, Rose
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.