Understanding the genetic factors behind complex traits and diseases
Deconstructing the Genetic Basis of Complex Trait Variation
This study is looking at how certain genes, especially those that don’t directly code for proteins, can affect health and diseases, using big health data to help us understand these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project ID | NIH-11020627 on NIH RePORTER |
What this research studies
This research investigates the genetic variants linked to complex traits and diseases by integrating insights from molecular biology and population genetics. It aims to identify which genes are most influential in these traits, particularly focusing on non-coding variants that are often overlooked. By utilizing large-scale biomedical datasets like the UK Biobank, the project will develop new statistical models to better understand the relationship between genetic variations and their biological functions. This interdisciplinary approach seeks to enhance our understanding of how genetics influences health and disease.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with complex traits or diseases that have a genetic component.
Not a fit: Patients with purely environmental or lifestyle-related conditions may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for drug development and personalized medicine based on genetic insights.
How similar studies have performed: Previous research using similar approaches has shown promise in uncovering genetic associations, suggesting that this project builds on a foundation of successful methodologies.
Where this research is happening
New York, United States
- New York University School of Medicine — New York, United States (Active)
Researchers
- Principal investigator: Mostafavi, Hakhamanesh — New York University School of Medicine
- Study coordinator: Mostafavi, Hakhamanesh
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.