Understanding the genetic factors behind complex traits and diseases
Official title: Deconstructing the Genetic Basis of Complex Trait Variation
Funded at New York University School of Medicine · NIH-11020627 · Data updated 2026-11-12
This study is looking at how certain genes, especially those that don’t directly code for proteins, can affect health and diseases, using big health data to help us understand these connections better.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | New York University School of Medicine NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 1, 2025 |
| Project end | March 31, 2030 |
| Funding year | 2025 |
| Award (this year) | $423,750 |
| NIH project number | 1R35GM157134-01 |
| Project ID | NIH-11020627 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with complex traits or diseases that have a genetic component.
✕Less likely to help
Patients with purely environmental or lifestyle-related conditions may not benefit from this research.
What this research studies
This research investigates the genetic variants linked to complex traits and diseases by integrating insights from molecular biology and population genetics. It aims to identify which genes are most influential in these traits, particularly focusing on non-coding variants that are often overlooked. By utilizing large-scale biomedical datasets like the UK Biobank, the project will develop new statistical models to better understand the relationship between genetic variations and their biological functions. This interdisciplinary approach seeks to enhance our understanding of how genetics influences health and disease.
Why it matters
Potential benefit: If successful, this research could lead to improved strategies for drug development and personalized medicine based on genetic insights.
How similar studies have gone: Previous research using similar approaches has shown promise in uncovering genetic associations, suggesting that this project builds on a foundation of successful methodologies.
Where this research is happening
-
New York University School of Medicine
New York, United States Active
Researchers
- Principal investigator: Mostafavi, Hakhamanesh — New York University School of Medicine
- Study coordinator: Mostafavi, Hakhamanesh
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.