Understanding the genetic factors affecting diabetes in the pancreas at a cellular level
Multi-omic genetic regulatory signatures underlying tissue complexity of diabetes in the pancreas at single-cell spatial resolution
This study is looking at how genes and the environment affect diabetes by examining the insulin-producing cells in the pancreas, and it aims to help people understand how diabetes develops so that better treatments can be created.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Michigan at Ann Arbor NIH-funded |
| Lab location | 1 site (Ann Arbor, United States) |
| Project ID | NIH-10908545 on NIH RePORTER |
What this research studies
This research investigates the complex genetic and environmental factors that contribute to diabetes, focusing specifically on the insulin-producing beta cells in the pancreas. By utilizing advanced techniques to analyze single cells, the study aims to map how genetic variations influence the function and arrangement of these cells across different ages and backgrounds. Patients may benefit from insights into how diabetes develops at a cellular level, potentially leading to more targeted treatments. The research employs a multi-omic approach, integrating various biological data to create a comprehensive picture of diabetes pathology.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals aged 21 and older who have been diagnosed with diabetes or are at risk for developing the condition.
Not a fit: Patients with diabetes-related complications that do not involve the pancreatic islets may not receive direct benefits from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for diabetes by identifying specific genetic factors that affect pancreatic function.
How similar studies have performed: Previous research has shown promise in understanding diabetes through genetic studies, but this approach of integrating multi-omic data at single-cell resolution is relatively novel.
Where this research is happening
Ann Arbor, United States
- University of Michigan at Ann Arbor — Ann Arbor, United States (Active)
Researchers
- Principal investigator: Parker, Stephen Cj — University of Michigan at Ann Arbor
- Study coordinator: Parker, Stephen Cj
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.