Understanding the genetic differences in PCOS among diverse populations
Official title: Elucidating the Genetic Architecture of Metabolic and Reproductive PCOS Subtypes in Diverse Populations
Funded at Icahn School of Medicine at Mount Sinai · NIH-10838466 · Data updated 2026-11-12
This study is looking at the genes that might play a role in polycystic ovary syndrome (PCOS) to help understand the different types of PCOS women can have, which could lead to better diagnoses and personalized treatments just for them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Icahn School of Medicine at Mount Sinai NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | August 1, 2020 |
| Project end | May 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $664,113 |
| NIH project number | 5R01HD100812-05 |
| Project ID | NIH-10838466 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are reproductive-age women diagnosed with polycystic ovary syndrome, particularly those from diverse ethnic backgrounds.
✕Less likely to help
Patients who do not have polycystic ovary syndrome or those outside the reproductive age group may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to polycystic ovary syndrome (PCOS), a common reproductive and metabolic disorder affecting many women. By analyzing genetic data from diverse populations, the study aims to identify distinct subtypes of PCOS based on reproductive and metabolic characteristics. The researchers will utilize advanced techniques such as genome-wide association studies (GWAS) and cluster analysis to uncover the underlying genetic architecture of these subtypes. This approach may lead to more accurate diagnoses and tailored treatments for women suffering from PCOS.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnostic criteria and personalized treatment options for women with PCOS.
How similar studies have gone: Previous research has shown success in identifying genetic factors associated with PCOS, but this study aims to explore novel subtypes, making it a potentially groundbreaking approach.
Where this research is happening
-
Icahn School of Medicine at Mount Sinai
New York, United States Active
Researchers
- Principal investigator: Dunaif, Andrea E — Icahn School of Medicine at Mount Sinai
- Study coordinator: Dunaif, Andrea E
Related research
Other NIH-funded projects on the same topics.
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Genetically Validated PCOS Subtypes for Better Diagnosis and Risk Stratification
Aimed at women with polycystic ovary syndrome (PCOS), this project uses genetic data and patient characteristics to define distinct PCOS subtypes and improve how we diagnose and estimate risk.
-
Understanding how PCOS develops during adolescence
This grant looks at how polycystic ovary syndrome begins in teenagers and what early signs help doctors diagnose it accurately.
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Genetically guided PCOS subtypes to improve diagnosis and risk stratification
Aims to use genetic patterns to identify PCOS subtypes so doctors can diagnose it more precisely and tailor risk predictions for each patient.
-
Using inositol to improve reproductive and metabolic health in women with PCOS
This study is looking at how taking inositol might help women with polycystic ovary syndrome (PCOS) by checking its effects on hormone levels and overall health over three months.
-
Understanding how dopamine affects reproductive hormone release in women with PCOS
This study is looking at how certain brain cells that control hormone release can help women with reproductive issues like PCOS and hypothalamic amenorrhea, and it’s testing if a compound that affects these cells can help balance hormone levels.
-
Investigating how genetic variations in gonadotropin pathways affect PCOS
This study is looking at how our genes might play a role in Polycystic Ovary Syndrome (PCOS) to help find better treatments for women dealing with this condition.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.