Understanding the genetic differences in endometrial cancer among African American women
Comprehensive molecular characterization of endometrial cancer, etiologic heterogeneity, and racial disparities
This study is looking at how endometrial cancer affects African American women differently, aiming to find out why they may face higher risks and worse outcomes, so we can better understand and help those who are impacted.
Quick facts
| Grant type | U01 cooperative agreement |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Brigham and Women's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11023083 on NIH RePORTER |
What this research studies
This research investigates the genetic and biological differences in endometrial cancer, particularly focusing on the disparities faced by African American women. By analyzing a large and diverse population, the study aims to uncover the unique genomic variations and risk factors associated with different tumor types. The approach includes comprehensive molecular characterization and the use of advanced bioinformatics to identify potential reasons for the higher mortality rates in African American patients. This research seeks to fill critical knowledge gaps regarding aggressive tumors that are often overlooked.
Who could benefit from this research
Good fit: Ideal candidates for this research include African American women diagnosed with endometrial cancer, as well as women from other racial and ethnic backgrounds with this condition.
Not a fit: Patients with endometrial cancer who are not African American or those with non-aggressive tumor types may not benefit directly from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved understanding and treatment options for endometrial cancer, particularly for African American women who face significant health disparities.
How similar studies have performed: Previous research has shown success in understanding cancer disparities through genomic studies, but this specific focus on endometrial cancer in African American women is relatively novel.
Where this research is happening
Boston, United States
- Brigham and Women's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: De Vivo, Immaculata — Brigham and Women's Hospital
- Study coordinator: De Vivo, Immaculata
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.