Understanding the genetic changes that lead to oral pre-cancerous conditions
Defining the mutational pathogenesis of oral preneoplasia
This study is looking at the genetic changes in early mouth lesions that could lead to cancer, to help doctors figure out which ones might turn into cancer and which ones won't, so they can provide better care for patients with these conditions.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of California, San Francisco NIH-funded |
| Lab location | 1 site (San Francisco, United States) |
| Project ID | NIH-11078007 on NIH RePORTER |
What this research studies
This research investigates the genetic mutations associated with oral preneoplastic diseases, which are conditions that can lead to oral cancer. By analyzing biopsies from patients over several years, the study aims to identify specific mutations that indicate whether these lesions will progress to cancer or remain stable. The approach involves advanced sequencing techniques to create a detailed map of the genetic changes in these lesions. This information could help develop better diagnostic tools and treatment strategies for patients with oral dysplasia.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals diagnosed with oral dysplasia or other pre-cancerous oral conditions.
Not a fit: Patients with no history of oral dysplasia or those who have already been diagnosed with advanced oral cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved methods for predicting which oral lesions are likely to progress to cancer, allowing for more personalized and effective treatment plans.
How similar studies have performed: Previous research has shown promise in identifying genetic markers for cancer progression in other types of malignancies, suggesting that this approach could yield valuable insights for oral preneoplasia as well.
Where this research is happening
San Francisco, United States
- University of California, San Francisco — San Francisco, United States (Active)
Researchers
- Principal investigator: Tward, Aaron — University of California, San Francisco
- Study coordinator: Tward, Aaron
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.