Understanding the genetic changes that lead to oral pre-cancerous conditions
Defining the mutational pathogenesis of oral preneoplasia
['FUNDING_R01'] · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · NIH-10820444
This study is looking at the genetic changes in early mouth lesions that could turn into cancer, to help doctors figure out which ones need treatment and which ones can just be watched over time.
Quick facts
| Phase | ['FUNDING_R01'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | UNIVERSITY OF CALIFORNIA, SAN FRANCISCO (nih funded) |
| Locations | 1 site (SAN FRANCISCO, UNITED STATES) |
| Trial ID | NIH-10820444 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic mutations associated with oral preneoplastic diseases, which can progress to oral squamous cell carcinoma. By analyzing biopsies from patients over time, the study aims to identify specific mutations that indicate whether these lesions are likely to become cancerous or can be safely monitored. The approach involves advanced next-generation sequencing techniques to map the genetic landscape of these lesions, ultimately seeking to improve patient management and treatment strategies.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals diagnosed with oral dysplastic lesions who are being monitored for potential progression to cancer.
Not a fit: Patients with no history of oral dysplastic lesions or those who have already been diagnosed with advanced oral cancer may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better diagnostic tools and treatment plans for patients with oral dysplasia, potentially preventing the progression to cancer.
How similar studies have performed: Previous research has shown promise in identifying genetic markers in other types of cancers, suggesting that this approach could yield valuable insights for oral preneoplasia as well.
Where this research is happening
SAN FRANCISCO, UNITED STATES
- UNIVERSITY OF CALIFORNIA, SAN FRANCISCO — SAN FRANCISCO, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: TWARD, AARON — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
- Study coordinator: TWARD, AARON
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.
Conditions: Cancers, neoplasm/cancer