Understanding the genetic changes that lead to brain tumors.
Official title: Modeling and Dissecting Epigenetic Drivers of Gliomagenesis
Funded at State University New York Stony Brook · NIH-10919832 · Data updated 2026-11-12
This study is looking at how certain changes in your genes might help brain tumors called diffuse gliomas grow, and it hopes to find new ways to treat these tumors better in the future.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | State University New York Stony Brook NIH-funded |
| Lab location | 1 site (Stony Brook, United States) |
| Project start | September 1, 2023 |
| Project end | August 31, 2026 |
| Funding year | 2024 |
| Award (this year) | $190,259 |
| NIH project number | 5R00CA267082-04 |
| Project ID | NIH-10919832 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals diagnosed with diffuse gliomas, particularly those with IDH1 mutations.
✕Less likely to help
Patients with other types of brain tumors that do not involve IDH1 mutations may not benefit from this research.
What this research studies
This research investigates the genetic and epigenetic factors that contribute to the development of diffuse gliomas, a type of aggressive brain tumor. It focuses on how mutations in the IDH1 gene lead to changes in DNA methylation patterns, which may silence tumor suppressor genes or activate oncogenes. By examining the three-dimensional structure of the genome and how it affects gene expression, the research aims to uncover new therapeutic targets for treating gliomas. Patients may benefit from insights that could lead to more effective treatments in the future.
Why it matters
Potential benefit: If successful, this research could lead to improved therapies for patients with diffuse gliomas.
How similar studies have gone: Previous research has shown promising results in understanding the genetic mechanisms of gliomas, indicating that this approach could yield valuable insights.
Where this research is happening
-
State University New York Stony Brook
Stony Brook, United States Active
Researchers
- Principal investigator: Rahme, Gilbert J — State University New York Stony Brook
- Study coordinator: Rahme, Gilbert J
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.