Understanding the genetic changes in Richter's syndrome related to chronic lymphocytic leukemia.
Official title: Defining the epigenetic landscape and therapeutic vulnerabilities of Richter's syndrome in CRISPR-based mouse models
Funded at Weill Medical Coll of Cornell Univ · NIH-11070208 · Data updated 2026-11-12
This study is looking at Richter's syndrome, a serious change in chronic lymphocytic leukemia, by creating mouse models to understand the genetic changes that happen during this transformation, which could help find better treatments for patients like you.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Weill Medical Coll of Cornell Univ NIH-funded |
| Lab location | 1 site (New York, United States) |
| Project start | May 19, 2023 |
| Project end | April 30, 2026 |
| Funding year | 2025 |
| Award (this year) | $196,020 |
| NIH project number | 5K22CA269556-03 |
| Project ID | NIH-11070208 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are patients diagnosed with chronic lymphocytic leukemia who may be at risk of developing Richter's syndrome.
✕Less likely to help
Patients with other types of leukemia or those who do not have chronic lymphocytic leukemia may not benefit from this research.
What this research studies
This research investigates Richter's syndrome, a severe complication of chronic lymphocytic leukemia (CLL), which transforms into a more aggressive form of cancer. Using advanced CRISPR technology, the team is creating mouse models that mimic human disease to explore the genetic and epigenetic changes that drive this transformation. By introducing specific mutations identified in human studies, the researchers aim to uncover how these changes affect the disease and identify potential new treatment strategies. This work could lead to a better understanding of the disease and pave the way for more effective therapies.
Why it matters
Potential benefit: If successful, this research could lead to new targeted therapies for patients suffering from Richter's syndrome.
How similar studies have gone: Previous research has shown success in using genetic models to study cancer transformations, indicating that this approach has potential for meaningful discoveries.
Where this research is happening
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Weill Medical Coll of Cornell Univ
New York, United States Active
Researchers
- Principal investigator: Ten Hacken, Elisa — Weill Medical Coll of Cornell Univ
- Study coordinator: Ten Hacken, Elisa
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.