Understanding the genetic causes of urinary stone disease
A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses
['FUNDING_CAREER'] · CASE WESTERN RESERVE UNIVERSITY · NIH-11003744
This study is looking at how our genes might play a role in urinary stone disease, which affects a lot of people, to help find new ways to understand and manage the condition better.
Quick facts
| Phase | ['FUNDING_CAREER'] |
|---|---|
| Study type | Nih_funding |
| Sex | All |
| Sponsor | CASE WESTERN RESERVE UNIVERSITY (nih funded) |
| Locations | 1 site (CLEVELAND, UNITED STATES) |
| Trial ID | NIH-11003744 on ClinicalTrials.gov |
What this research studies
This research investigates the genetic factors contributing to urinary stone disease (USD), which affects one in eight Americans. By combining monogenic and polygenic analyses, the study aims to identify novel genetic variants associated with USD. Patients will undergo whole genome and exome sequencing to uncover both single-gene and gene-gene interactions that may influence the risk of developing stones. The findings could lead to the development of a new risk score that integrates genetic information for better clinical management of USD.
Who could benefit from this research
Good fit: Ideal candidates for this research include individuals with a history of urinary stone disease or those at high risk due to family history.
Not a fit: Patients who do not have urinary stone disease or are not at risk for developing it may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for urinary stone disease based on individual genetic profiles.
How similar studies have performed: Previous research has shown promise in identifying genetic factors related to urinary stone disease, but this comprehensive approach combining monogenic and polygenic analyses is relatively novel.
Where this research is happening
CLEVELAND, UNITED STATES
- CASE WESTERN RESERVE UNIVERSITY — CLEVELAND, UNITED STATES (ACTIVE)
Researchers
- Principal investigator: WU, CHEN-HAN WILFRED — CASE WESTERN RESERVE UNIVERSITY
- Study coordinator: WU, CHEN-HAN WILFRED
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.