Understanding the genetic causes of urinary stone disease
Official title: A comprehensive approach to understanding the genetic causes of urinary stone disease: combining monogenic and polygenic analyses
Funded at Case Western Reserve University · NIH-11003744 · Data updated 2026-11-12
This study is looking at how our genes might play a role in urinary stone disease, which affects a lot of people, to help find new ways to understand and manage the condition better.
Quick facts
| Grant type | Career grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Case Western Reserve University NIH-funded |
| Lab location | 1 site (Cleveland, United States) |
| Project start | January 1, 2024 |
| Project end | December 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $161,535 |
| NIH project number | 5K08DK135933-02 |
| Project ID | NIH-11003744 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a history of urinary stone disease or those at high risk due to family history.
✕Less likely to help
Patients who do not have urinary stone disease or are not at risk for developing it may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to urinary stone disease (USD), which affects one in eight Americans. By combining monogenic and polygenic analyses, the study aims to identify novel genetic variants associated with USD. Patients will undergo whole genome and exome sequencing to uncover both single-gene and gene-gene interactions that may influence the risk of developing stones. The findings could lead to the development of a new risk score that integrates genetic information for better clinical management of USD.
Why it matters
Potential benefit: If successful, this research could lead to improved prevention and treatment strategies for urinary stone disease based on individual genetic profiles.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to urinary stone disease, but this comprehensive approach combining monogenic and polygenic analyses is relatively novel.
Where this research is happening
-
Case Western Reserve University
Cleveland, United States Active
Researchers
- Principal investigator: Wu, Chen-Han Wilfred — Case Western Reserve University
- Study coordinator: Wu, Chen-Han Wilfred
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.