Understanding the genetic causes of strabismus
Molecular mechanisms underlying strabismus risk
This study is looking at how certain genes might play a role in causing strabismus, or crossed eyes, especially a type called esotropia, to help us understand it better and find new ways to treat it.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project ID | NIH-11001448 on NIH RePORTER |
What this research studies
This research investigates the genetic factors that contribute to strabismus, a condition where the eyes do not properly align. It focuses on identifying specific genetic duplications that increase the risk of developing esotropia, a type of strabismus. The study will explore how these genetic changes affect gene expression and the structure of chromatin, which may influence visual function. By examining patients with strabismus, the research aims to uncover the underlying mechanisms that lead to this condition and improve treatment options.
Who could benefit from this research
Good fit: Ideal candidates for this research include children aged 0-11 years who have a family history of strabismus or exhibit symptoms of the condition.
Not a fit: Patients who are older than 11 years or do not have a family history of strabismus may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for children with strabismus.
How similar studies have performed: Previous research has shown promise in understanding genetic factors related to strabismus, but this specific approach is novel and aims to provide deeper insights.
Where this research is happening
Boston, United States
- Boston Children's Hospital — Boston, United States (Active)
Researchers
- Principal investigator: Whitman, Mary Catherine — Boston Children's Hospital
- Study coordinator: Whitman, Mary Catherine
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.