Understanding the Genetic Causes of Mouth and Face Birth Defects
Genetic underpinnings of craniofacial disorders explored with spatial sequencing
This research aims to understand the genetic instructions that guide the development of the mouth and face to help prevent common birth defects like cleft lip and dental problems.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Washington NIH-funded |
| Lab location | 1 site (Seattle, United States) |
| Project ID | NIH-11089524 on NIH RePORTER |
What this research studies
Many children are born with conditions affecting their mouth and face, such as cleft lip or palate and dental issues. To find ways to prevent these conditions, we need to deeply understand how genes control the development of these areas. This project uses advanced techniques to map out the genetic activity in human fetal tissue at different stages of development. By creating a detailed map of gene activity, we hope to uncover the specific genetic causes of these birth defects.
Who could benefit from this research
Good fit: This foundational research is for anyone interested in the genetic origins of craniofacial birth defects, as it aims to benefit future patients with conditions like cleft lip, cleft palate, and dental anomalies.
Not a fit: Patients currently living with these conditions may not see immediate direct benefit from this foundational research, as it focuses on early development and prevention.
Why it matters
Potential benefit: If successful, this work could lead to new ways to identify risks and develop preventative therapies for common birth defects of the mouth and face.
How similar studies have performed: While studies in animal models have provided valuable insights, this project uses novel spatial sequencing techniques on human tissue to uncover human-specific genetic details.
Where this research is happening
Seattle, United States
- University of Washington — Seattle, United States (Active)
Researchers
- Principal investigator: Ruohola-Baker, Hannele — University of Washington
- Study coordinator: Ruohola-Baker, Hannele
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.