Understanding the genetic causes of infantile epilepsies and their effects
Official title: Molecular Genetic Mechanisms of Infantile Epilepsies and the Impact of Genetic Diagnosis
Funded at Boston Children's Hospital · NIH-11030869 · Data updated 2026-11-12
This study is looking at the genes that might cause epilepsy in babies under five, to help families understand their child's condition better and find the best treatments to support their development.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Boston Children's Hospital NIH-funded |
| Lab location | 1 site (Boston, United States) |
| Project start | January 1, 2025 |
| Project end | December 31, 2029 |
| Funding year | 2025 |
| Award (this year) | $230,904 |
| NIH project number | 1K23NS140397-01 |
| Project ID | NIH-11030869 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are infants under five years old who have unexplained epilepsy.
✕Less likely to help
Patients with well-defined causes of epilepsy that are not genetic in nature may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to infantile epilepsies, which affect infants under five years old. By using advanced genomic techniques, the study aims to identify new genetic causes of these conditions and assess how genetic diagnoses can influence treatment and developmental outcomes. Families of infants with unexplained epilepsy will be followed over time to evaluate the impact of genetic findings on their child's health and development. This approach seeks to enhance the understanding of these complex conditions and improve precision therapies for affected infants.
Why it matters
Potential benefit: If successful, this research could lead to more effective treatments and better developmental outcomes for infants with epilepsy.
How similar studies have gone: Other research has shown promise in identifying genetic causes of epilepsy, suggesting that this approach could yield valuable insights.
Where this research is happening
-
Boston Children's Hospital
Boston, United States Active
Researchers
- Principal investigator: D'gama, Alissa Maria — Boston Children's Hospital
- Study coordinator: D'gama, Alissa Maria
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.