Understanding the genetic causes of hidradenitis suppurativa
Official title: Determining the Genetic Basis of Hidradenitis Suppurativa
Funded at Univ of North Carolina Chapel Hill · NIH-10981410 · Data updated 2026-11-12
This study is looking at how genes might play a role in hidradenitis suppurativa (HS), a skin condition that can really affect young people's lives, and it involves gathering blood samples from around 2,000 patients to find new genetic clues that could lead to better treatments.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Univ of North Carolina Chapel Hill NIH-funded |
| Lab location | 1 site (Chapel Hill, United States) |
| Project start | August 22, 2024 |
| Project end | July 31, 2029 |
| Funding year | 2024 |
| Award (this year) | $459,879 |
| NIH project number | 1R01AR083790-01A1 |
| Project ID | NIH-10981410 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals aged 12-20 who have been diagnosed with hidradenitis suppurativa.
✕Less likely to help
Patients who do not have hidradenitis suppurativa or are outside the age range of 12-20 may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to hidradenitis suppurativa (HS), a chronic skin condition that significantly impacts quality of life, particularly in adolescents and young adults. By analyzing genetic data from a diverse group of 2,000 patients, the study aims to identify new genetic variants associated with HS, building on previous findings from smaller studies. The research will also explore how these genetic factors affect skin cells and inflammation, potentially leading to new treatment options. Patients may be asked to provide blood samples and participate in assessments to help uncover these genetic links.
Why it matters
Potential benefit: If successful, this research could lead to better understanding and treatment options for patients suffering from hidradenitis suppurativa.
How similar studies have gone: Previous studies have successfully identified genetic factors in hidradenitis suppurativa, but this research aims to expand on those findings with a larger and more diverse cohort.
Where this research is happening
-
Univ of North Carolina Chapel Hill
Chapel Hill, United States Active
Researchers
- Principal investigator: Sayed, Christopher J — Univ of North Carolina Chapel Hill
- Study coordinator: Sayed, Christopher J
Related research
Other NIH-funded projects on the same topics.
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Anti-CD38 immunotherapy for severe hidradenitis suppurativa
A new treatment using anti-CD38 therapy is being tested for people with severe hidradenitis suppurativa who have not responded to prior therapies.
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Botulinum toxin blocks nerve signals to immune cells to treat hidradenitis suppurativa
This NIH grant tests a new approach to hidradenitis suppurativa by using botulinum toxin to interrupt nerve signals that may drive skin inflammation in patients.
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Precision therapies for hidradenitis suppurativa using AI
A doctor-researcher team at UC San Francisco is using advanced computer methods to find personalized drug options to treat hidradenitis suppurativa.
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Injectable Hydrogel for HS: a localized therapy to ease painful skin disease
A new baricitinib hydrogel is being developed to deliver pain relief and reduce inflammation directly in hidradenitis suppurativa (HS) lesions, potentially lowering systemic side effects.
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Whole-genome sequencing to understand hidradenitis suppurativa in diverse groups
Researchers will study the genetic factors that contribute to hidradenitis suppurativa, especially in African American, Hispanic/Latino, and White patients, to better understand why some people are more affected.
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Understanding the Genes Behind Hidradenitis Suppurativa in teens and young adults
A study to find genetic factors that contribute to hidradenitis suppurativa (HS), a painful skin condition that often starts in adolescence and affects many Black individuals.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.