Understanding the genetic causes of hereditary prostate cancer
The Genetic Origin of Hereditary Prostate Cancer
This study is looking at the genes of men who have a strong family history of prostate cancer to find out what makes them more likely to get the disease, with the hope that this information can lead to better treatments and help families understand their cancer risks.
Quick facts
| Grant type | NIH-funded research |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Veterans Health Administration NIH-funded |
| Lab location | 1 site (Nashville, United States) |
| Project ID | NIH-11135292 on NIH RePORTER |
What this research studies
This research investigates the genetic origins of hereditary prostate cancer, particularly focusing on men with a strong family history of the disease. By comparing these individuals to those without such a history, the study aims to identify specific genetic markers that contribute to the risk of developing prostate cancer. The approach utilizes advanced genetic sequencing techniques to uncover inherited and somatic mutations that may drive the disease. This knowledge could help tailor precision therapies for affected individuals and improve understanding of familial cancer risks.
Who could benefit from this research
Good fit: Ideal candidates for participation are men with a strong family history of prostate cancer who are seeking to understand their genetic risk.
Not a fit: Patients without a family history of prostate cancer or those with sporadic cases may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to more effective and personalized treatment options for men at high risk of hereditary prostate cancer.
How similar studies have performed: Previous research has shown promise in identifying genetic factors in other hereditary cancers, suggesting that this approach could yield valuable insights for prostate cancer as well.
Where this research is happening
Nashville, United States
- Veterans Health Administration — Nashville, United States (Active)
Researchers
- Principal investigator: Smith, Jeffrey R. — Veterans Health Administration
- Study coordinator: Smith, Jeffrey R.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.