Understanding the genetic causes of heart failure in older adults
Integrative genomic and transcriptomic investigation of human heart failure mechanisms
This study is looking at how our genes might affect the risk of heart failure in people aged 65 and older, with the hope of finding new ways to understand and treat the condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project ID | NIH-11076309 on NIH RePORTER |
What this research studies
This research investigates the genetic factors contributing to heart failure, particularly in individuals aged 65 and older. By analyzing a large dataset of human heart samples, the study aims to identify both rare genetic mutations and common variants that influence the risk of developing heart failure. The researchers will explore how these genetic factors interact and contribute to the disease's progression, potentially leading to new insights into heart failure mechanisms. Patients may benefit from a better understanding of their genetic risk and more personalized treatment options based on these findings.
Who could benefit from this research
Good fit: Ideal candidates for this research are individuals aged 65 and older who may be at risk for or currently experiencing heart failure.
Not a fit: Patients under the age of 65 or those without any genetic predisposition to heart failure may not benefit from this research.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for heart failure, particularly for older adults.
How similar studies have performed: Previous research has shown promise in using integrated genomic approaches to understand complex diseases, suggesting that this methodology could yield valuable insights into heart failure.
Where this research is happening
Aurora, UNITED STATES
- University of Colorado Denver — Aurora, United States (Active)
Researchers
- Principal investigator: Taylor, Matthew R — University of Colorado Denver
- Study coordinator: Taylor, Matthew R
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page below.