Understanding the genetic causes of heart failure in older adults
Official title: Integrative genomic and transcriptomic investigation of human heart failure mechanisms
Funded at University of Colorado Denver · NIH-11076309 · Data updated 2026-11-12
This study is looking at how our genes might affect the risk of heart failure in people aged 65 and older, with the hope of finding new ways to understand and treat the condition better.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | University of Colorado Denver NIH-funded |
| Lab location | 1 site (Aurora, UNITED STATES) |
| Project start | April 17, 2024 |
| Project end | March 31, 2028 |
| Funding year | 2025 |
| Award (this year) | $631,780 |
| NIH project number | 5R01HL170012-02 |
| Project ID | NIH-11076309 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research are individuals aged 65 and older who may be at risk for or currently experiencing heart failure.
✕Less likely to help
Patients under the age of 65 or those without any genetic predisposition to heart failure may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to heart failure, particularly in individuals aged 65 and older. By analyzing a large dataset of human heart samples, the study aims to identify both rare genetic mutations and common variants that influence the risk of developing heart failure. The researchers will explore how these genetic factors interact and contribute to the disease's progression, potentially leading to new insights into heart failure mechanisms. Patients may benefit from a better understanding of their genetic risk and more personalized treatment options based on these findings.
Why it matters
Potential benefit: If successful, this research could lead to improved diagnosis and treatment strategies for heart failure, particularly for older adults.
How similar studies have gone: Previous research has shown promise in using integrated genomic approaches to understand complex diseases, suggesting that this methodology could yield valuable insights into heart failure.
Where this research is happening
-
University of Colorado Denver
Aurora, United States Active
Researchers
- Principal investigator: Taylor, Matthew R — University of Colorado Denver
- Study coordinator: Taylor, Matthew R
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About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.