Understanding the genetic causes of heart failure
Official title: From genetic basis to mechanisms for Heart Failure
Funded at Broad Institute, INC. · NIH-11028426 · Data updated 2026-11-12
This study is looking into how our genes might play a role in heart failure, which affects many people, to help find better and more personalized treatments for those who need them.
Quick facts
| Grant type | R01 grant |
|---|---|
| Study type | NIH-funded research |
| Funding institution | Broad Institute, INC. NIH-funded |
| Lab location | 1 site (Cambridge, United States) |
| Project start | January 3, 2025 |
| Project end | November 30, 2028 |
| Funding year | 2025 |
| Award (this year) | $817,208 |
| NIH project number | 1R01HL177209-01 |
| Project ID | NIH-11028426 on NIH RePORTER |
Who could benefit from this research
✓Could help
Ideal candidates for this research include individuals with a diagnosis of heart failure or those at high risk due to genetic factors.
✕Less likely to help
Patients with heart failure caused solely by non-genetic factors may not benefit from this research.
What this research studies
This research investigates the genetic factors contributing to heart failure, a condition affecting millions globally. By utilizing advanced techniques like Cell Painting and Perturb-seq, the study aims to identify specific genes and their roles in heart failure mechanisms. The goal is to accelerate the understanding of how these genes influence heart function, which could lead to the development of targeted therapies. Patients may benefit from new treatment options that are more effective and personalized based on genetic insights.
Why it matters
Potential benefit: If successful, this research could lead to the development of more effective and targeted therapies for heart failure patients.
How similar studies have gone: Previous research has shown promise in identifying genetic factors related to heart failure, indicating that this approach could yield significant insights.
Where this research is happening
-
Broad Institute, INC.
Cambridge, United States Active
Researchers
- Principal investigator: Xiao, Ling — Broad Institute, INC.
- Study coordinator: Xiao, Ling
Related research
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AI-assisted heart failure diagnosis in Rwanda using focused ultrasound
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HF endotypes in heart failure using ethical multi-modal AI and molecular data
A patient-friendly project that uses advanced AI and multiple kinds of health data to identify distinct heart failure subtypes that could guide personalized care.
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Digital-first heart failure care delivery in Uganda
A targeted program in Uganda tests a digital care plan to help people with heart failure manage their symptoms at home.
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Digital-first heart failure care delivery in Uganda
A study to test digital self-care tools to help people with heart failure in Uganda manage symptoms and stay healthier.
About this research
- This is an active NIH-funded research project — typically early-stage science, not a clinical trial accepting patient enrollment.
- Some NIH-funded labs run parallel clinical studies or seek volunteers for related work. To check, contact the principal investigator or institution listed above.
- For full project details, budget, and progress reports, visit the official NIH RePORTER page.